To say that George Lopez has had a varied show-business career would be an understatement.

His career versatility has allowed him to be a near constant fixture on television for the better part of the past decade and a go-to voice actor for kid flicks such as “Rio” and “Beverly Hills Chihuahua” for even longer.

The actor-comedian — performing at the Funny Bone Comedy Club on Friday through Sunday — has also starred in live-action features such as “Valentine’s Day” and “Balls of Fury.” He had his own hit prime-time family sitcom, “The George Lopez Show, which ran for six seasons on ABC, and a late-night talk show, “Lopez Tonight,” on TBS from 2009 to 2011.

Earlier this year, the native of Mission Hills, Calif., returned to network television as host of the Fox dating program “Take Me Out.” Through his many endeavors, however, Lopez never completely gave up on live comedy, which is where he speaks his mind.

His latest stand-up special, “It’s Not Me, It’s You,” premiered on HBO in July. Lopez spends the bulk of the special drawing on his Mexican-American experiences to compare and contrast the differences between Latinos and non-Latinos. He frequently slips from English to Spanish to act out a bit as he puts a humorous spin on race relations in the United States from bigotry and stereotypes to parenting and work habits.

Even when Lopez seems to stray off topic, he turns the conversation back toward his Latino worldview. Lopez jokes that during a visit with President Obama, he stole from the White House, where he was served corn tortillas.

It’s not exactly George Carlin-level social commentary, but Lopez offers enough insights and unexpected twists to keep the audience members at the taping of this special in stitches from beginning to end.